Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement.
نویسندگان
چکیده
We report a systematic review and meta-analysis of published randomised controlled trials evaluating the efficacy of tranexamic acid (TXA) in reducing blood loss and transfusion in total hip replacement (THR). The data were evaluated using the generic evaluation tool designed by the Cochrane Bone, Joint and Muscle Trauma Group. We identified 11 clinical trials which were suitable for detailed extraction of data. There were no trials that used TXA in revision THR. A total of seven studies (comprising 350 patients) were eligible for the blood loss outcome data. The use of TXA reduced intra-operative blood loss by a mean of 104 ml (95% confidence interval (CI) -164 to -44, p = 0.0006, heterogeneity I(2) 0%), postoperative blood loss by a mean of 172 ml (95% CI -263 to -81, p = 0.0002, heterogeneity I(2) 63%) and total blood loss by a mean of 289 ml (95% CI -440 to -138, p < 0.0002, heterogeneity I(2) 54%). TXA led to a significant reduction in the proportion of patients requiring allogeneic blood transfusion (risk difference -0.20, 95% CI -0.29 to -0.11, p < 0.00001, I(2) 15%). There were no significant differences in deep-vein thrombosis, pulmonary embolism, infection rates or other complications among the study groups.
منابع مشابه
Comparison of efficacy and safety of topical versus intravenous tranexamic acid in total hip arthroplasty
BACKGROUND The study aimed to compare the effectiveness and safety of topical versus intravenous (IV) tranexamic acid (TXA) for reducing blood loss in primary total hip arthroplasty (THA). METHODS This systematic review and meta-analysis were performed according to the preferred reporting items for systematic reviews and meta-analyses statement criteria. PubMed, Embase, the Cochrane Library, ...
متن کاملPrevention of post-operative anaemia in hip and knee arthroplasty--a systematic review.
INTRODUCTION Patient blood management strategies for total hip and knee arthroplasty are controversial. They range from pre-operative haemoglobin optimisation to intra- and post-operative interventions. The aim of this study was to assess the various treatment modalities with respect to blood loss, haemoglobin levels and blood transfusions. METHODS The analysis was based on the principles of ...
متن کاملEfficiency of tranexamic acid in perioperative blood loss in hip arthroplasty: a systematic literature review and meta-analysis.
INTRODUCTION AND OBJECTIVE Tranexamic acid (TXA) is an antifibrinolytic drug used to reduce bleeding in mortality risk situations such as trauma. Our objective was to conduct a systematic literature review to evaluate the effectiveness and safety of TXA in reducing bleeding in hip arthroplasty. MATERIAL AND METHODS A systematic literature review and meta-analysis of primary studies similar to...
متن کاملSystematic review and meta-analysis of diagnostic value of epicutaneous patch testing in patients with oral lichenoid lesions
BACKGROUND AND AIM: We sought to carry out a systematic review and meta-analysis of the diagnostic value of epicutaneous patch testing in patients with oral lichenoid lesions (OLLs). METHODS: Bibliographic searches were conducted in electronic databases such as PubMed, the Cochrane library, EBSCO, Scopus, Web of knowledge and Google scholar from January 1990 to December 2011. Search terms re...
متن کاملMeta-analysis of Intravenous Tranexamic Acid in Primary Total Hip Arthroplasty.
Previous meta-analyses established that tranexamic acid confers benefits when used during total hip arthroplasty (THA). However, 2 of these meta-analyses included a variety of routes of administration of tranexamic acid in THA (topical, intravenous, oral, and intra-articular), another meta-analysis included a variety of antifibrinolytic drugs (not restricted to a single drug), and the final met...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of bone and joint surgery. British volume
دوره 93 1 شماره
صفحات -
تاریخ انتشار 2011